Chapter 4: Central nervous system
The clinical guidance contained in the linked documents is believed to be true and accurate at the point of preparation. New evidence/ guidance is continually released which may supersede this information; please use your own clinical and professional judgement when reading or acting on any information contained.
- Alcohol Detox Guidance approved 2018.pdf [pdf] 467KB
- Antidepressant Guidelines approved 2020.pdf [pdf] 199KB
- Antipsychotics - ECG monitoring for adults (approved July 2018).pdf [pdf] 33KB
- Antipsychotics - Depot or LAI by unlicensed route (Approved May 18).pdf [pdf] 20KB
- Antipsychotics - CAMHS Information and record book for Young People and their families.pdf[pdf] 627KB
- Antipsychotics - CAMHS Reference card. Evidence base regarding side effects in children and young people.pdf[pdf] 131KB
- Antipsychotic - High Dose Therapy Checklist (approved 2020).pdf [pdf] 252KB
- Antipsychotic - High Dose Therapy Monitoring Sheet (approved 2020).pdf [pdf] 412KB
- Antipsychotic - High Dose Therapy Prescribing Guidance (approved 2020).pdf [pdf] 745KB
- Antipsychotics & Mood Stabilsers - Summary monitoring guidance for adults (approved 2022).pdf [pdf] 600KB
- Antipsychotics and plasma level monitoring incl smoking effects November 2020.pdf [pdf] 248KB
- Antipsychotics - Prescribing Guidance (approved 2015).pdf [pdf] 567KB
- Antipsychotics - Unlicensed use in unipolar depression (approved 2010).pdf [pdf] 25KB
- Antipsychotics - Unlicensed use of atypicals in the treatment of Generalised Anxiety Disorder (approved 2011).pdf [pdf] 41KB
- Antipsychotics - POMH Ready Reckoner (LATEST version) (The POMH Ready Reckoner is available to Coventry and Warwickshire Partnership NHS Trust staff only. This link will re-direct you to the Trust intranet)
- Aripiprazole long acting injection (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Atomoxetine – Shared Care Agreement SCA002
- Baclofen - Unlicensed use for the maintenance of abstinence from alcohol (approved 2011).pdf [pdf] 25KB
- Buccal Midazolam or Rectal Diazepam - Treatment of seizures (approved 2016).pdf [pdf] 189KB
- Bupropion - Unlicensed use in depression (approved 2009).pdf [pdf] 33KB
- Bupropion - Unlicensed use in adults with ADHD (approved 2011).pdf [pdf] 35KB
- Buspirone - Unlicensed use in treatment resistant depression (approved 2011).pdf [pdf] 59KB
- Cannabis based products for medicinal use - Prescribing position - Nov 2018.pdf [pdf] 85KB
- Citalopram and Escitalopram - Unlicensed prescribing when contraindicated due to QTc (approved 2012.pdf [pdf] 356KB
- Citalopram and Escitalopram - Unlicensed use where there is a contraindication due to QTc issues (approved 2012).pdf [pdf] 33KB
- Clonidine - Unlicensed use in childhood sleep disturbances (approved 2010).pdf [pdf] 28KB
- Clonidine - Unlicensed use in Hypersalivation caused by Clozapine (approved 20 11).pdf [pdf] 28KB
- Clozapine - Alternatives to Hyoscine for Clozpaine induced hypersalivation (approved 2017).pdf [pdf] 88KB
- Clozapine change intervention leaflet.pdf [pdf] 236KB
- Clozapine - Community initiation - Approved Sept D&T 2023 revised Sept 24.pdf [pdf] 495KB
- Clozapine - Inpatient Initiation Guidance Approved February 2024 revised Sept 24.pdf [pdf] 732KB
- Clozapine - Unlicenced use after a red blood result (approved 2011).pdf [pdf] 30KB
- Clozapine - Unlicensed use in the treatment of resistant psychotic depression (approved 2010).pdf [pdf] 34KB
- Dementia Medicines - Prescribing Algorithm Across the primary and secondary care interface (2020).pdf [pdf] 54KB
- Dexamfetamine – Shared Care Agreement SCA003 (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Domperidone checklist children 24th February 2020.pdf 379KB
- Esketamine DPS post July 2020 D&T Discussion .pdf [pdf] 260KB
- Epilepsy - Care Plan (approved 2015).pdf [pdf] 423KB
- Fluoxetine - Unlicensed use in the treatment of anxiety in autistic children (approved 2010).pdf [pdf] 41KB
- Fluoxetine – Shared Care Agreement SCA048(This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Hyperprolactinaemia APD Algorithm approved D&T January 2019.pdf [pdf] 86KB
- Hyoscine - Unlicensed use in hypersalivation caused by Clozapine (approved 2009).pdf [pdf] 31KB
- Lamotrigine - Unlicensed use in the treatment of borderline personality disorder (approved 2011).pdf [pdf] 31KB
- Lithium - Prescribing Guidance (approved 2017).pdf [pdf] 283KB
- Lithium – Shared Care Agreement SCA005 (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Lurasidone – Drug Position Statement (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Melatonin for children - Prescribing Support Information Approved D&T March 23 updated March 2024.pdf [pdf] 394KB
- Melatonin Specialist Initiation Drug Checklist (SIDC) (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Methylphenidate – Shared Care Agreement SCA001 (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Methylphenidate - Brand change letter Concerta to Xaggitin.pdf [pdf] 240KB
- Methylphenidate MR formulation review - Jan 2025 D&T.pdf [pdf] 220KB
- Metformin - Unlicensed use to prevent antipsychotic-induced weight gain (approved Sept 2016).pdf [pdf] 174KB
- Naltrexone - Unlicensed use in alcohol dependence (approved 2011).pdf [pdf] 42KB
- Naltrexone - Unlicensed use in self injurious behaviour (approved 2009).pdf [pdf] 31KB
- Nicotine Replacement Therapy - General Prescribing and Usage Advice V1.3.pdf [pdf] 228KB
- Nicotine Replacement Therapy - Administration Record for PRN products (approved 2015).pdf [pdf] 180KB
- NRT or ENDS admin prior to prescription v1.2 approved Nov 2020.pdf [pdf] 337KB
- Guidance for the Recommended Supply of Nicotine Replacement Therapy (NRT) to Clients Aged 12 and Over.pdf [pdf] 791KB
- Olanzapine Depot (Zypadhera) - Drug position statement (approved 2014).pdf [pdf] 281KB
- Opiods - Patient Information Leaflet (2015).pdf [pdf] 227KB
- Oxcarbazepine - Unlicensed use in the treatment of bipolar affective disorder (approved 2010).pdf [pdf] 37KB
- Paliperidone ER Tablets (Invega) - Treatment of Schizophrenia.pdf [pdf] 186KB
- Paliperidone Palmitate Long Acting Injection – 1 and 3 monthly. (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Penfluridol - Evidence for use in the treatment of schizophrenia (approved 2015).pdf [pdf] 32KB
- Pirenzepine - Unlicensed use in Clozapine related hypersalivation (approved 2009).pdf [pdf] 32KB
- Reboxetine Drug position statement (approved 2011).pdf [pdf] 36KB
- Risperdal Consta - Unlicensed use above the licensed dose (approved 2009).pdf [pdf] 38KB
- Risperidone Consta - High dose Guidance (approved 2010).pdf [pdf] 37KB
- Substance Misuse Guidance (Enc 3B).pdf [pdf] 1MB
- Terazosin - Use in Hypersalivation (approved 2017).pdf [pdf] 121KB
- Topiramate - Unlicensed use as a mood stabiliser (approved 2012).pdf [pdf] 66KB
- Topiramate - Unlicensed use in post traumatic stress disorder Bulimia Nervosa (approved 2009).pdf [pdf] 32KB
- Trazodone - Unlicensed use in the treatment of the behavioural and psychological symptoms of dementia (approved 2011).pdf [pdf] 40KB
- Tryptophan – Shared Care Agreement SCA049 (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Valproate - Continuing prescribing in CWPT for females up to 55 years [pdf] 98KB
- Valproate - Initiating prescribing in CWPT for females up to 55 years [pdf] 97KB
- Valproate - Initiating prescribing in CWPT for males up to 55 years old [pdf] 92KB
- Valproate MHRA Guidance approved May 2024 D&T[pdf] 501KB
- Valproate & Valproic Acid – Shared Care Agreement (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Vortioxetine – Drug Position Statement (This link will re-direct you to the Area Prescribing Committee website. Type in the name of the drug required in the netFormulary search box)
- Valproic acid formulation comparison